Watch Breakthrough for Free: How to Stream the Movie Online at 123Movies. . Breakthrough tells the story of a renegade scientist’s quest to find a cure for cancer, the disease that killed his mother. Texan Jim Allison is a 2018 Nobel Prize winner for discovering how to prompt a cancer patient’s own immune system into defeating their disease, but for decades he waged an often-lonely struggle against the painful skepticism of the medical establishment.